Endocrine Abstracts

Background: Current guidance for the management of macroprolactinomas recommends full pituitary profile at baseline and subsequently only if symptomatic. Pituitary adenomas that co-secrete growth hormone and prolactin at presentation are well-recognised. Case reports of acromegaly after prolactinoma treatment are associated with symptomatic acromegaly. We present two patients with asymptomatic acromegaly years after diagnosis of macroprolactinoma.Patient...

Case history: A 34-year old Caucasian nurse presented to her GP with a 7 month history of abdominal pain. She was found to have PTH-dependent hypercalcaemia with Stage 3A chronic kidney disease (corrected calcium 3.43 mmol/l, phosphate 0.62 mmol/l, total vitamin D 32 nmol/l, PTH 214.9 pmol/l, creatinine 117 μmol/l and eGFR 45 ml/min/1.73m2). On direct questioning, she reported fatigue, generalised weakness and intermittent joint pains affecting her lower back and bo...

A 30-year-old man of Asian descent presented to the emergency department with recurrent episodes of sudden onset limb weakness and difficulty walking over a period of 3 years. Each episode resolved within 2–3 h and he had fully normal mobility in between episodes. He denied any visual, bulbar symptoms or other focal neurology. He had a 9 year history of Graves’ disease for which he had recently discontinued carbimazole therapy in preparation fo...

Background: Patients with primary adrenal insufficiency (PAI) carry an increased risk of infections which can precipitate adrenal crises. They are thought to be more likely to contract COVID-19 and develop severe disease; however, little is known about the true impact of COVID-19 on these patients.Objectives: To assess the response of a large single-centre cohort of PAI patients to COVID-19, focusing on morbidity and health promotion attitudes.<p cla...